In animal reproduction reports, codeine administered from the oral path to pregnant rats throughout the duration of organogenesis improved resorptions and lessened fetal weights in a dose around 25 moments the maximum proposed human dose (MRHD) while in the presence of maternal toxicity (see Info).

Considering that recurrences of NMS happen to be documented with phenothiazines, keep away from utilization of promethazine HCl and codeine phosphate oral Resolution in clients with a heritage consistent with NMS.

Everyday living-threatening respiratory depression and death have transpired in young children who received codeine; most instances adopted tonsillectomy and/or adenoidectomy, and lots of of the children had proof of currently being an ultra-rapid metabolizer of codeine because of a CYP2D6 polymorphism. (five.3) Promethazine HCl and codeine phosphate oral solution is contraindicated in small children youthful than 12 yrs of age and in children youthful than 18 many years of age pursuing tonsillectomy and/or adenoidectomy.

Codeine Codeine and its Energetic metabolite, morphine, are current in human milk. You can find published scientific tests and cases that have documented too much sedation, respiratory despair and death (in a single infant) in infants exposed to codeine through breast milk. Girls who're extremely-quick metabolizers of codeine realize increased than expected serum levels of morphine, probably leading to greater levels of morphine in breast milk that may be harmful in their breastfed infants.

Due to pitfalls of habit, abuse and misuse, the lowest dose for your shortest duration reliable with specific individual treatment objectives should be made use of.

Use with warning; start with lower doses or with for a longer period dosing intervals and titrate little by little whilst diligently checking for Unwanted effects.

Because of the possible for promethazine to reverse epinephrine’s vasopressor influence, epinephrine should NOT be read more employed to deal with hypotension associated with promethazine overdose.

Published studies with codeine have claimed inconsistent results and have significant methodological limitations (see Details). You will discover studies of respiratory despair when codeine is utilised throughout labor and supply (see Medical Considerations).

This isn't a complete listing of Negative effects along with other major Negative effects or health problems may possibly occur because of using this drug.

The phosphate salt of codeine takes place as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and marginally soluble in alcohol. The molecular weight is 406.37. Its molecular components is C18H21NO3•H3PO4 • ½ H2O, and it's got the next chemical structure.

Promethazine HCl and codeine phosphate oral Resolution is for oral use only. Abuse of promethazine HCl and codeine phosphate oral Alternative poses a risk of overdose and death.

two)]. Instruct patients to acquire methods to retailer promethazine HCl and codeine phosphate oral solution securely and also to correctly get rid of unused promethazine HCl and codeine phosphate oral solution in accordance with the community state pointers and/or regulations.

five.eighteen Severe Hypotension Promethazine HCl and codeine phosphate oral Alternative may trigger significant hypotension which include orthostatic hypotension and syncope in ambulatory people. You can find increased danger in patients whose capability to maintain blood pressure has currently been compromised by a decreased blood volume or concurrent administration of particular CNS depressant medicines (e.

Stimulation may very well be evident, particularly in young children and geriatric people. Convulsions may seldom take place. A paradoxical response has long been noted in young children getting single doses of seventy five mg to one hundred twenty five mg orally, characterized by hyperexcitability and nightmares.